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Invitrogen™ Progerin Monoclonal Antibody (13A4D4)
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Catalog No. PIMA518073
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100 μL
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PIMA518073 100 μL
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Catalog No. PIMA518073 Supplier Invitrogen™ Supplier No. MA518073
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Description

Mouse Monoclonal Antibody

This antibody specifically recognizes Progerin (Lamin A delta50) and does not cross-react with endogenous prelamin A. Western blot results show a band at approximately 70 kDa.

Progerin is a 614 amino acid protein involved in Hutchinson-Gilford progeria syndrome. Progerin is most often generated by a point mutation (C1824T) in the LMNA gene that codes for lamin-A/C. This mutation activates a cryptic splice site and gives rise to a form of lamin A with a 50-amino acid internal deletion within the C-terminal domain of the protein. Approximately 80% of Hutchinson-Gilford progeria syndrome cases carry a single copy of the most common mutation, a silent point mutation, G608G (GGC > GGT), within exon 11 of the LMNA gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Progerin
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 13A4D4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene LMNA
Gene Accession No. P02545
Gene Alias 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A/C; lamin A/C-like 1; Lamin AC; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; Mutant lamin A/C; Prelamin-A/C; PRO1; progerin mutant; Renal carcinoma antigen NY-REN-32
Gene Symbols LMNA
Host Species Mouse
Immunogen Synthetic peptide conjugated to KLH derived from within residues 604-611 (GAQSPQNC) at the C terminus of Human Progerin.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4000
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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