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Invitrogen™ Progranulin Monoclonal Antibody (2D4-2F1)
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Catalog No. PIMA1187
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200 μL
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Catalog No. Quantity
PIMA1187 200 μL
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Catalog No. PIMA1187 Supplier Invitrogen™ Supplier No. MA1187
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Description

Mouse Monoclonal Antibody

By Western blot, MA1-187 detects Human Progranulin at ~85 kDa.

Progranulin is the precursor protein of Granulin also called as Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature Granulin. Both Granulin and smaller cleavage product of Granulin regulates cell growth. Progranulin stimulates proliferation of many epithelial cells, promotes their anchorage-independent growth and, when overexpressed, confers epithelial tumorigenicity. Progranulin/epithelin gene is multifunctional, with important constitutive roles in epithelial homeostasis, reproductive, immunological, and neuronal function. Progranulin constitutively expressed in a number of epithelia, particularly in the skin, GI tract, and reproductive system. Progranulin is expressed in immune cells in vivo and in specific neurons in the brain.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Progranulin
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2D4-2F1
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
Gene GRN
Gene Accession No. P28799
Gene Alias Acrogranin; acrogranulin; CLN11; epithelin; Epithelin precursor; Epithelin/granulin precursor; Epithelin-1; Epithelin-2; GEP; Glycoprotein of 88 Kda; GP88; granulin; Granulin A; Granulin B; Granulin C; Granulin D; Granulin E; Granulin F; Granulin G; Granulin precursor; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7; granulin-epithelin; granulins; GRN; Paragranulin; PC cell-derived growth factor; PCDGF; PEPI; Pgrn; Proepithelin; progranulin
Gene Symbols GRN
Host Species Mouse
Immunogen Recombinant human Progranulin.
Purification Method Protein A
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2896
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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