Invitrogen™ Protein APC Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530580

Catalog No. PIPA530580

Description

Recommended positive controls: 293T, A431, HeLa, HepG2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Specifications

• Antigen: Protein APC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Apc
• Gene Alias: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli protein; AI047805; APC; APC, WNT signaling pathway regulator; AU020952; AW124434; BTPS2; CC1; Deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; GS; mAPC; Min; multiple intestinal neoplasia; PPP1R46; Protein APC; protein phosphatase 1, regulatory subunit 46; RATAPC; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11789, 24205, 324
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1.44 mg/mL
• Formulation: PBS with 20% glycerol and 0.025% ProClin 300; pH 7
• Gene Accession No.: P25054, P70478, Q61315
• Gene Symbols: Apc
• Immunogen: Synthetic peptide corresponding to a region within amino acids 2767 and 2843 of Human APC.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov