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Invitrogen™ PRPF39 Polyclonal Antibody
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Catalog No. PIPA521627
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PIPA521627 100 μL
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Catalog No. PIPA521627 Supplier Invitrogen™ Supplier No. PA521627
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Raji, 293T, human 3xFlag-PRPF39 transfected 293T. Predicted reactivity: Mouse (98%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The PRPF39 gene plays a critical role as a splicing factor involved in alternative splicing regulation. In humans, it is homologous to the yeast Prp39 and Prp42 paralogs, forming a homodimer that interacts with the carboxy-terminal domain (CTD) of U1C, a parallel mechanism observed in the yeast Prp39/Prp42 heterodimer. Recent studies have highlighted its impact on splicing efficiency through knockdown experiments in HEK293 cells, which revealed significant changes in the expression of many genes, underscoring its importance in splicing adaptability according to cell type-specific needs. Additionally, PRPF39 is found to be highly expressed in Acute Lymphoblastic Leukemia (ALL), with research suggesting that targeting PRPF39 for degradation could contribute to the treatment of ALL. Phylogenetic analyses indicate a coevolution of PRPF39 expression with molecular components like shortened U1 snRNA, reflecting the splicing complexity across different species. The gene is also involved in the regulation of distant genes which are relevant to cellular responses, such as those involved in cisplatin response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRPF39
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, RNA Immunoprecipitation
Classification Polyclonal
Concentration 0.67 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene PRPF39
Gene Accession No. Q86UA1
Gene Alias flj11128; flj20666; flj45460; mgc149842; mgc149843; pre-mRNA processing factor 39; pre-mRNA-processing factor 39; PRP39 homolog; PRP39 pre-mRNA processing factor 39 homolog; PRP39 pre-mRNA processing factor 39 homolog (yeast); PRPF39; Srcs1; v-src suppressed transcript 1
Gene Symbols PRPF39
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human PRPF39. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55015
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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