Invitrogen™ PRPK Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590145

Catalog No. PIPA590145

Description

Immunogen sequence: MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD EVRLRGRKRS MVG; Positive Samples: HT-29, BxPC3, 293T, HeLa, Jurkat, Mouse testis, Mouse thymus, Rat testis; Cellular Location: Nucleus.

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). [UniProt].

Specifications

• Antigen: PRPK
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tp53rk
• Gene Alias: 2810408M09Rik; 4933401B08Rik; 5630401H01Rik; Atypical serine/threonine protein kinase TP53RK; BUD32; C20orf64; dJ101A2; EKC/KEOPS complex subunit TP53RK; mNori-2p; Nori-2; Nori-2p; p53-related protein kinase; PRPK; TP53 regulating kinase; TP53-regulating kinase; TP53RK; transformation related protein 53 regulating kinase; Trp53 regulating kinase; Trp53rk; Trp53tk
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 112858, 362272, 76367
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.37 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q96S44
• Gene Symbols: Tp53rk, Trp53rkb
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-253 of human TP53RK (NP_2910283).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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