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Invitrogen™ PRRX1 Monoclonal Antibody (OTI1E10)
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Catalog No. PIMA526580
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PIMA526580 100 μL
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Catalog No. PIMA526580 Supplier Invitrogen™ Supplier No. MA526580
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Description

Mouse Monoclonal Antibody

PRRX1 Monoclonal Antibody for IHC (P), Western Blot

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRRX1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1E10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PRRX1
Gene Accession No. P54821
Gene Alias A230024N07Rik; AA755424; AGOTC; AI385634; AI843499; Homeobox protein K-2; homeobox protein mHox; Homeobox protein PHOX1; K-2; mHox; paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; paired mesoderm homeobox protein 1; paired related homeobox 1; paired-related homeobox protein 1; PHOX1; Pmx; Pmx1; Prrx1; Prx1; PRX-1; rHox
Gene Symbols PRRX1
Host Species Mouse
Immunogen Full length human recombinant protein of PRRX1 produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5396
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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