Invitrogen™ PRRX1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA538008

Catalog No. PIPA538008

Description

A recommended positive control is HeLa cell lysate. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.

Specifications

• Antigen: PRRX1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRRX1
• Gene Alias: A230024N07Rik; AA755424; AGOTC; AI385634; AI843499; Homeobox protein K-2; homeobox protein mHox; Homeobox protein PHOX1; K-2; mHox; paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; paired mesoderm homeobox protein 1; paired related homeobox 1; paired-related homeobox protein 1; PHOX1; Pmx; Pmx1; Prrx1; Prx1; PRX-1; rHox
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18933, 266813, 5396
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P54821, P63013, P63014
• Gene Symbols: PRRX1
• Immunogen: 19 amino acid peptide near the center of human PRRX1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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