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Invitrogen™ PRRX1 Polyclonal Antibody
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Catalog No. PIPA538008
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100 μg
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Catalog No. Quantity
PIPA538008 100 μg
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Catalog No. PIPA538008 Supplier Invitrogen™ Supplier No. PA538008
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Description

Rabbit Polyclonal Antibody

A recommended positive control is HeLa cell lysate. At least two isoforms of PRRX1 are known to exist; this antibody will detect both isoforms.

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRRX1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PRRX1
Gene Accession No. P54821, P63013, P63014
Gene Alias A230024N07Rik; AA755424; AGOTC; AI385634; AI843499; Homeobox protein K-2; homeobox protein mHox; Homeobox protein PHOX1; K-2; mHox; paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; paired mesoderm homeobox protein 1; paired related homeobox 1; paired-related homeobox protein 1; PHOX1; Pmx; Pmx1; Prrx1; Prx1; PRX-1; rHox
Gene Symbols PRRX1
Host Species Rabbit
Immunogen 19 amino acid peptide near the center of human PRRX1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18933, 266813, 5396
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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