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Invitrogen™ PRRX1 Polyclonal Antibody
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Catalog No. PIPA5106700
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PIPA5106700 100 μL
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Catalog No. PIPA5106700 Supplier Invitrogen™ Supplier No. PA5106700
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PRRX1.

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRRX1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PRRX1
Gene Accession No. P54821, P63013, P63014
Gene Alias A230024N07Rik; AA755424; AGOTC; AI385634; AI843499; Homeobox protein K-2; homeobox protein mHox; Homeobox protein PHOX1; K-2; mHox; paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; paired mesoderm homeobox protein 1; paired related homeobox 1; paired-related homeobox protein 1; PHOX1; Pmx; Pmx1; Prrx1; Prx1; PRX-1; rHox
Gene Symbols PRRX1
Host Species Rabbit
Immunogen A synthesized peptide derived from human PRRX1(Accession P54821), corresponding to amino acid residues A53-S103.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18933, 266813, 5396
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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