Invitrogen™ PSA Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA185819

Catalog No. PA185819

Description

Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is human prostate. Sheep anti Human prostate specific antigen antibody recognizes human prostate specific antigen, a 33-34 kDa glycoprotein with chymotrypsin-like protease activity.

PSA is a chymotrypsin-like serine protease (kallikrein family) produced by the prostate epithelium, and is abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia. PSA is used to confirm prostatic acinar cell origin in primary and metastatic carcinoma and to rule out non-prostatic carcinoma mimics.

Specifications

• Antigen: PSA
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: KLK3
• Gene Alias: Antigen; antigen, prostate specific; APS; Fletcher factor; gamma-seminoprotein; hK3; Kal3; Kal-3; Kallikrein 3; kallikrein 3, plasma; kallikrein B, plasma 1; kallikrein related peptidase 3; kallikrein-3; Kallikrein-3 (KLK3); kallikrein-related peptidase 3; Kalp1; KALP15; Kininogenin; KLK2A1; Klk3; KLK-3; Klkb1; P-30 antigen; Pk; Plasma kallikrein; Plasma kallikrein heavy chain; Plasma kallikrein light chain; Plasma prekallikrein; prostate specific antigen; prostate-specific (APS); prostate-specific antigen; PSA; Semenogelase; seminin
• Host Species: Sheep
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 354
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin)
• Concentration: 5 mg/mL
• Formulation: PBS with 0.09% sodium azide
• Gene Accession No.: P07288
• Gene Symbols: KLK3
• Immunogen: Purified human prostate specific antigen from human seminal fluid.
• Quantity: 1 mL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG