Invitrogen™ PSEN2 Monoclonal Antibody (APS 21)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA1753

Catalog No. MA1-753

Description

MA1-753 detects presenilin 2 protein (PS2) from rat, mouse, human, and nonhuman primate samples. No cross-reactivity is seen with presenilin 1. MA1-753 has successfully been used in immuno-fluorescence, Western blot and ELISA procedures. By Western blot, this antibody detects an ~28 kDa protein representing PS2 NT (N-terminus fragment) and the ~46 kDa full-length PS2 from transfected COS-7 cells. In 4% paraformaldehyde fixed COS-7 cells transfected with hPS2, MA1-753 showed specific Golgi, nuclear envelope, and ER labeling. The MA1-753 immunogen is a synthetic peptide corresponding to residues C(31) Q E G R Q G P E D G E N T A(45) of human PS2.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

Specifications

• Antigen: PSEN2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: O88777, P49810, Q61144
• Gene Symbols: PSEN2
• Immunogen: Synthetic peptide corresponding to residues C(31) Q E G R Q G P E D G E N T A(45) of human PS2.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Monkey
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: APS 21
• Conjugate: Unconjugated
• Gene: PSEN2
• Gene Alias: AD3L; AD3LP; AD4; Ad4h; AD5; Alg3; ALG-3; Alzheimer disease 4; CMD1V; E5-1; presenilin 2; presenilin-2; Presenilin-2 CTF subunit; Presenilin-2 NTF subunit; PS2; Ps-2; PSEN 2; PSEN2; Psnl2; STM2; STM-2
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 19165, 5664, 81751
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid