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Invitrogen™ PSMB9 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA11960
Description
PA1-1960 detects proteasome 20S LMP2 from human and mouse cells. PA1-1960 can be successfully used in Western blot procedures. By Western blot this antibody detects an ~23 kDa protein representing proteasome 20S LMP2 from mouse embryo fibroblast cell extract. This antibody also recognizes a band at ~24 kDa, which may correspond to LMP2 precursor protein. The PA1-1960 immunogen is a mixture of synthetic peptides corresponding to residues C R(207) V I L G N/D E L P K F Y D E(220) of human and mouse proteasome 20S LMP2. These peptides are available for use in neutralization and control procedures. PA1-1960 can be used with blocking peptide PEP-176.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.
Specifications
PSMB9 | |
Polyclonal | |
Unconjugated | |
Psmb9 | |
beta1i; large multifunctional peptidase 2; large multifunctional protease 2; LMP2; Lmp-2; LMP-2d; low molecular mass polypeptide 2; low molecular mass protein 2; Macropain chain 7; MGC70470; multicatalytic endopeptidase complex chain 7; proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteasome (prosome, macropain) subunit, beta type, 9; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); proteasome 20S subunit beta 9; proteasome beta 9 subunit; proteasome catalytic subunit 1i; proteasome chain 7; proteasome subunit beta 6i; proteasome subunit beta 9; proteasome subunit beta type 9; proteasome subunit beta type-9; Proteasome subunit beta-1i; proteasome-related gene 2; proteosome (prosome, macropain) subunit, beta type 9; proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteosome beta 9 subunit; PSMB6i; PSMB9; Really interesting new gene 12 protein; Ring12; RING12 protein | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
16912, 5698 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 1 mg/mL BSA and 0.05% sodium azide | |
P28065, P28076 | |
Psmb9 | |
Mixture of synthetic peptides corresponding to residues C R(207) V I L G N/D E L P K F Y D E(220) of human and mouse proteasome 20S LMP2. | |
100 μg | |
Primary | |
Human, Mouse | |
Antibody | |
IgG |
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