Invitrogen™ PSMB9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA11960

Catalog No. PA11960

Description

PA1-1960 detects proteasome 20S LMP2 from human and mouse cells. PA1-1960 can be successfully used in Western blot procedures. By Western blot this antibody detects an ~23 kDa protein representing proteasome 20S LMP2 from mouse embryo fibroblast cell extract. This antibody also recognizes a band at ~24 kDa, which may correspond to LMP2 precursor protein. The PA1-1960 immunogen is a mixture of synthetic peptides corresponding to residues C R(207) V I L G N/D E L P K F Y D E(220) of human and mouse proteasome 20S LMP2. These peptides are available for use in neutralization and control procedures. PA1-1960 can be used with blocking peptide PEP-176.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.

Specifications

• Antigen: PSMB9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Psmb9
• Gene Alias: beta1i; large multifunctional peptidase 2; large multifunctional protease 2; LMP2; Lmp-2; LMP-2d; low molecular mass polypeptide 2; low molecular mass protein 2; Macropain chain 7; MGC70470; multicatalytic endopeptidase complex chain 7; proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteasome (prosome, macropain) subunit, beta type, 9; proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2); proteasome 20S subunit beta 9; proteasome beta 9 subunit; proteasome catalytic subunit 1i; proteasome chain 7; proteasome subunit beta 6i; proteasome subunit beta 9; proteasome subunit beta type 9; proteasome subunit beta type-9; Proteasome subunit beta-1i; proteasome-related gene 2; proteosome (prosome, macropain) subunit, beta type 9; proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2); proteosome beta 9 subunit; PSMB6i; PSMB9; Really interesting new gene 12 protein; Ring12; RING12 protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16912, 5698
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P28065, P28076
• Gene Symbols: Psmb9
• Immunogen: Mixture of synthetic peptides corresponding to residues C R(207) V I L G N/D E L P K F Y D E(220) of human and mouse proteasome 20S LMP2.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG