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PeproTech PSPN Polyclonal Antibody, PeproTech®, Invitrogen™

Catalog No. 500P1381MG
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50 μg
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500P1381MG 1 mg
500P13850UG 50 μg
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Catalog No. 500P1381MG Supplier PeproTech Supplier No. 500P1381MG
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Description

Rabbit Polyclonal Antibody

AA Sequence of recombinant protein: RALSGPCQLW SLTLSVAELG LGYASEEKVI FRYCAGSCPR GARTQHGLAL ARLQGQGRAH GGPCCRPTRY TDVAFLDDRH RWQRLPQLSA AACGCGG. Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human Persephin. Anti-Human Persephin-specific antibody was purified by affinity chromatography employing an immobilized Human Persephin matrix. Sandwich ELISA: To detect Human Persephin by sandwich ELISA (using 100 μL/well antibody solution) a concentration of 0.5-2.0 μg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human Persephin (500-P138Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human Persephin. Western Blot: To detect Human Persephin by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 μg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human Persephin is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.

Persephin is a disulfide-linked, homodimeric, neurotrophic factor structurally related to GDNF, artemin, and neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFR alpha (alpha1-alpha4) receptors. The GFRalpha4 was first identified in chicken, and was later shown to be the preferential binding subunit for persephin. Persephin promotes the survival of ventral midbrain dopaminergic neurons and motor neurons after sciatic nerve oxotomy, and, like GDNF, promotes ureteric bud branching. However, in contrast to GDNF and neurturin, persephin does not support the survival of peripheral neurons.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSPN
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.1-1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene PSPN
Gene Accession No. O60542
Gene Alias Persephin; PSP; Pspn
Gene Symbols PSPN
Host Species Rabbit
Immunogen E.coli-derived Recombinant Human Persephin.
Purification Method Antigen affinity chromatography
Quantity 1 mg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5623
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
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