Invitrogen™ PTBP1 Monoclonal Antibody (1)

Catalog No.	Quantity
32-480-0	100 μg

Catalog No. 32-480-0 Supplier Invitrogen™ Supplier No. 324800

Description

Mouse Monoclonal Antibody

This antibody reacts with the C-terminus of the human and rodent PTB protein.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Specifications

• Antigen: PTBP1
• Applications: Flow Cytometry, Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry
• Classification: Monoclonal
• Clone: 1
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene: PTBP1
• Gene Accession No.: P17225, P26599, Q00438
• Gene Alias: 57 kDa RNA-binding protein PPTB-1; AA407203; AL033359; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; HNRNPI; HNRNP-I; HNRPI; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; polypyrimidine tract-binding protein; polypyrimidine tract-binding protein 1; polypyrimidine-tract binding protein; pPTB; PTB; PTB-1; PTB2; PTB3; PTB4; PTBP1; PTB-T; Pybp; Pybp1; Pybp2; pyrimidine binding protein 1; pyrimidine binding protein 2; RNA-binding protein
• Gene Symbols: PTBP1
• Host Species: Mouse
• Immunogen: Recombinant human PTB protein.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19205, 29497, 5725
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1