Invitrogen™ PTBP1 Recombinant Rabbit Monoclonal Antibody (JU41-20)

Catalog No.	Quantity
PIMA534617	100 μL

Catalog No. PIMA534617 Supplier Invitrogen™ Supplier No. MA534617

Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: Jurkat, A549, LOVO, human tonsil tissue, human skin tissue, human kidney tissue, mouse colon tissue.

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Specifications

• Antigen: PTBP1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: JU41-20
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 40% glycerol, 0.05% BSA and 0.05% sodium azide; pH 7.4
• Gene: PTBP1
• Gene Accession No.: P26599
• Gene Alias: 57 kDa RNA-binding protein PPTB-1; AA407203; AL033359; Heterogeneous nuclear ribonucleoprotein I; heterogeneous nuclear ribonucleoprotein polypeptide I; hnRNP I; HNRNPI; HNRNP-I; HNRPI; MGC10830; MGC8461; polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I); polypyrimidine tract binding protein 1; polypyrimidine tract-binding protein; polypyrimidine tract-binding protein 1; polypyrimidine-tract binding protein; pPTB; PTB; PTB-1; PTB2; PTB3; PTB4; PTBP1; PTB-T; Pybp; Pybp1; Pybp2; pyrimidine binding protein 1; pyrimidine binding protein 2; RNA-binding protein
• Gene Symbols: PTBP1
• Host Species: Rabbit
• Immunogen: Synthetic peptide within Human PTBP1 aa 20-69.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5725
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles, store in dark
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG