Invitrogen™ PTPN2 Recombinant Rabbit Monoclonal Antibody (JE57-07)

Catalog No.	Quantity
PIMA544846	100 μL

Catalog No. PIMA544846 Supplier Invitrogen™ Supplier No. MA544846

Description

Rabbit Recombinant Monoclonal Antibody

PTPN2 Recombinant Monoclonal Antibody for Western Blot, Flow

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.

Specifications

• Antigen: PTPN2
• Applications: Flow Cytometry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: JE57-07
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: PTPN2
• Gene Accession No.: P17706, P35233, Q06180
• Gene Alias: AI325124; hypothetical protein LOC540888; MPTP; protein tyrosine phosphatase non-receptor type 2; protein tyrosine phosphatase, non-receptor type 2; protein-tyrosine phosphatase PTP-2; Protein-tyrosine phosphatase PTP-S; PTN2; PTPN 2; PTPN2; Ptpt; T cell protein-tyrosine phosphatase; TC PTP; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCELLPTP; TCPTP; TC-PTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2
• Gene Symbols: PTPN2
• Host Species: Rabbit
• Immunogen: Recombinant protein within human TCPTP aa 1-100/415.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 117063, 19255, 5771
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG