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PTRH2/BIT1 Polyclonal Antibody, Bethyl Laboratories

Catalog No. p-7143452
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50-156-9854 20 μL
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Catalog No. 50-156-9854 Supplier Bethyl Laboratories, Inc Supplier No. A305224AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apoptosis induced by integrin detachment. Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process. Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE. Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

Specifications

Antigen PTRH2/BIT1
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene PTRH2
Gene Accession No. Q9Y3E5
Gene Alias OTTHUMP00000205936; PTH 2; bcl-2 inhibitor of transcription 1; peptidyl-tRNA hydrolase 2, mitochondrial
Gene Symbols PTRH2
Host Species Rabbit
Immunogen Between 129 and 179
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51651
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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