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  6. Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered

Puromycin dihydrochloride, 10 mg/ml in distilled water, sterile-filtered

Catalog No. AAJ67236XF
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Description

Puromycin (puromycine, CAS # 58-58-2) is a bacteriostatic antibiotic that acts as an aminoacyl-tRNA analog and disrupts protein synthesis. | CAS: 58-58-2 | C22H31Cl2N7O5 | 544.43 g/mol

Puromycin is also used as a substrate of Mdr-1. It is been widely used in cell culture applications. It also induces apoptosis which was found as parallel apoptosis caused by deprivation of neuronal growth factor (NGF) in developing chick sympathetic neurons; however, this apoptotic activity can be inhibited by several transcriptional inhibitors such as: actinomycin D and α-amanitin (sc-202440) which has lead researchers to hypothesize that apoptosis is triggered through the transcription of particular genes. Shown to arrest cells in G2/M phase. Puromycin is an inhibitor of CD13 and DPP7.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Puromycin (puromycine) is an aminoglycoside antibiotic originating from Streptomyces alboniger
  • It acts as an aminoacyl tRNA analog and prematurely terminates peptide elongation
  • Puromycin has effects on both prokaryotes and eukaryotes
  • Puromycin may also have neoplastic activity

Application

  • Puromycin can be used for research use as an immunofluorescent target, in antibiotic resistance testing, or for studies on drug mechanisms
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 58-58-2
Molecular Formula C22H31Cl2N7O5
Molecular Weight (g/mol) 544.43
MDL Number MFCD00150080
InChI Key MKSVFGKWZLUTTO-MLYJQVMKNA-N
PubChem CID 439530
ChEBI CHEBI:17939
SMILES Cl.Cl.COC1=CC=C(C[C@H](N)C(=O)N[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O)N2C=NC3=C(N=CN=C23)N(C)C)C=C1

Specifications

Type Puromycin Dihydrochloride
Physical Form Liquid
Packaging Plastic Bottle
Quantity 1 mL
Solubility Information Soluble in water (50mg/ml at 20°C).
IUPAC Name (2S)-2-amino-N-[(2S,3S,4R,5R)-5-[6-(dimethylamino)-9H-purin-9-yl]-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]-3-(4-methoxyphenyl)propanamide dihydrochloride
Chemical Name or Material Puromycin dihydrochloride

Safety and Handling

Hazard Category H302
Precautionary Statement P264b-P270-P301+P312-P330-P501c
RTECSNumber AU7350000
TSCA No
Recommended Storage Store at -20°C
SDS

RUO – Research Use Only

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