PYGL Mouse anti-Human, Clone: 1G12D8, Proteintech

Catalog No.	Quantity
50-173-7175	150 μL

Catalog No. 50-173-7175 Supplier Proteintech Group Inc Supplier No. 667691IG150UL

Description

Mouse Monoclonal Antibody

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: PYGL
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 1G12D8
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: PYGL
• Gene Accession No.: P06737
• Gene Alias: GSD6, phosphorylase, glycogen, liver, PYGL
• Gene Symbols: PYGL
• Host Species: Mouse
• Immunogen: PYGL Fusion Protein Ag8550
• Purification Method: Protein G
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5836
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1