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Invitrogen™ PYGO2 Polyclonal Antibody
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Catalog No. PIPA534878
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100 μL
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PIPA534878 100 μL
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Catalog No. PIPA534878 Supplier Invitrogen™ Supplier No. PA534878
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NIH-3T3, A549, H1299, HCT116, Huh7. Predicted reactivity: Human (98%), Mouse (100%), Rat (100%), Pig (98%), Bovine (98%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PYGO2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene PYGO2
Gene Accession No. Q9BRQ0
Gene Alias 1190004M21Rik; mpygo2; PP7910; PYGO2; pygopus 2; pygopus family PHD finger 2; pygopus homolog 2; RGD1308535
Gene Symbols PYGO2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of mouse Pygopus 2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 68911, 90780
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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