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Apexbio Technology LLC PYR-41 418805-02-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B14925.1
PYR-41 (CAS 418805-02-4) is a selective inhibitor of ubiquitin-activating enzyme (E1) involved in the ubiquitination cascade essential for diverse cellular processes such as protein degradation apoptosis DNA repair and signaling pathways By inhibiting E1 activity PYR-41 impedes ubiquitination reactions resulting in decreased proteasomal degradation In vitro studies demonstrate that PYR-41 also increases overall cellular SUMOylation and attenuates cytokine-induced NF- B activation through interference with TRAF6-dependent (non-proteasomal) ubiquitination and stabilization of I B Currently PYR-41 remains in preclinical research serving primarily as an investigative tool to explore ubiquitination mechanisms and related signal transduction pathways
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