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Tocris Bioscience™ PYR 41
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Catalog No. 297810
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29-781-0 10mg
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Description

Ubiquitin-activating enzyme (E1) inhibitor

Cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Blocks ubiquitination and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.

Specifications

CAS 418805-02-4
Quantity 10 mg
Molecular Formula C17H13N3O7
Formula Weight 371.3
Purity >98%
Molecular Weight (g/mol) 371.305
Chemical Name or Material PYR 41

Safety and Handling

Recommended Storage Store at -20°C
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