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Apexbio Technology LLC Pyridone 6 457081-03-7 5mg
SDP

Supplier:  Apexbio Technology LLC A37415

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Pyridone 6 (CAS 457081-03-7) is a reversible ATP-competitive inhibitor of Janus kinases (JAKs) exhibiting high selectivity with IC50 values of 15 nM for JAK1 1 nM for JAK2 5 nM for JAK3 and 1 nM for TYK2 It demonstrates markedly reduced activity against other kinases (IC50 130 nM) Pyridone 6 disrupts JAK-STAT signaling suppressing cytokine-induced STAT3 phosphorylation and reducing cellular proliferation in relevant models such as B9 and U266 cells Its utility extends to animal models where it has been employed to study immune modulation and inflammation including atopic dermatitis by inhibiting Th cell differentiation and mast cell function

Catalog No. 50-224-0167


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