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  5. Tocris Bioscience™ PZM21

Tocris Bioscience™ PZM21
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Catalog No. 721850
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72-185-0 50 mg
72-181-0 10 mg
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Catalog No. 72-185-0 Supplier Tocris Bioscience™ Supplier No. 7218/50
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Description

Selective μ receptor agonist

PZM21 is a selective μ receptor agonist (EC50 = 4.6 nM). PZM21 has been reported to exhibit bias for the Gi signaling pathway over arrestin-3. The compound exhibits 500-fold selectivity for μ over δ receptors and no detectable activity at κ or nociceptin receptors and a panel of 316 other GPCRs. PZM21 induces analgesia in a mouse hot plate assay, but not a tail-flick assay and exhibits no significant conditioned place preference response in in vivo assays. CNS penetrant.

Specifications

Chemical Name or Material N-[(2 S)-2-(Dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(1 S)-1-methyl-2-(3-thienyl)ethyl]urea
CAS 1997387-43-5
Quantity 50 mg
Target mu Opioid Receptor Agonists
Molecular Formula C19H27N3O2S
Purity 0.98
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