R&D Systems™ Quantikine Immunoassay Control 1105 for h/cm PD-L1/B7-H1

Catalog No.	Quantity
QC226	1 Ea.

Catalog No. QC226 Supplier R&D Systems™ Supplier No. QC226

Description

For use with catalog number DB7H10

• Programmed Death Ligand 1
• PD-L1, also known as B7-H1 and CD274, is an approximately 65 kDa transmembrane glycoprotein in the B7 family of immune regulatory molecules.
• PD-L1 is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, enothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma.
• PD-L1 binds to T cell B7-1/CD80 and PD-1.
• It suppresses T cell activation and proliferation and induces the apoptosis of activated T cells.
• It plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development.
• PD-L1 favors the development of anti-inflammatory IL-10 and IL-22 producing dendritic cells and inhibits the development of Th17 cells.
• In cancer, PD-L1 provides resistance to T cell mediated lysis, enhances EMT, and enhances the tumorigenic function of Th22 cells.

Specifications

• Product Type: ELISA
• For Use With (Application): Control
• For Use With (Equipment): Catalog number DB7H10
• Gene ID (Entrez): 29126
• Host Species: Human, Cynomolgus Monkey
• Quantity: 1 Ea.
• Storage Requirements: Store the unopened product at 2°C to 8°C. Do not use past expiration date.
• Synonym: Avelumab, B7-H, B7H1, B7-H1, B7H1PDCD1L1, CD274, CD274 antigenMGC142294, CD274 molecule, PDCD1L1, PDCD1LG1, PDCD1LG1MGC142296, PDL1, PD-L1, PD-L1B7 homolog 1, PDL1PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1
• Target: PD-L1