R&D Systems™ Quantikine Immunoassay Control Set 232, Human TNF-alpha HS

Description

Immunoassay control set for Human Tumor Necrosis Factor protein levels

Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF2, is prototypic ligand of TNF superfamily. It is pleiotropic molecule that plays central role in inflammation, apoptosis, immune system development. TNF-α is produced by wide variety of immune, epithelial cell types. Human TNF-α consists of 35 amino acid (aa) cytoplasmic domain, 21 aa transmembrane segment, 177 aa extracellular domain (ECD). Within ECD, human TNF-α shares 97% aa sequence identity with rhesus and 71% - 92% with bovine, canine, cotton rat, equine, feline, mouse, porcine, and rat TNF-α. The 26 kDa type 2 transmembrane protein is assembled intracellularly to form noncovalently linked homotrimer. Ligation of this complex induces reverse signaling that promotes lymphocyte costimulation but diminishes monocyte responsiveness. Cleavage of membrane bound TNF-α by TACE/ADAM17 releases 55 kDa soluble trimeric form of TNF-α. TNF-α trimers bind ubiquitous TNF RI and hematopoietic cell-restricted TNF RII, both of which are also expressed as homotrimers. TNF-α regulates lymphoid tissue development through control of apoptosis. It also promotes inflammatory responses by inducing activation of vascular endothelial cells and macrophages. TNF-α is key cytokine in development of several inflammatory disorders. It contributes to development of type 2 diabetes through its effects on insulin resistance and fatty acid metabolism.

• Storage: Store unopened product at 2 to 8°C. Do not use past expiration date.

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Specifications

• Content And Storage: Store the unopened product at 2°C to 8°C. Do not use past expiration date.
• Type: Control Set for ELISA Kit
• Gene ID (Entrez): 7124 (Human); 21926 (Mouse); 24835 (Rat); 397086 (Porcine); 280943 (Bovine); 403922 (Canine); 100033834 (Equine); 493755 (Feline); 100009088 (Rabbit)
• Intended Use: For quantitative measurement of Tumor Necrosis Factor Alpha protein levels
• Product Name: Immunoassay Control Set 929
• Source: Human
• Target Gene: Tumor Necrosis Factor alpha

For Research Use Only