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Tocris Bioscience™ (R)-(+)-Bay K 8644
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Catalog No. 154510
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15-451-0 10 mg
15-455-0 50 mg
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Catalog No. 15-451-0 Supplier Tocris Bioscience™ Supplier No. 1545/10
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Description

CaV1.x blocker; (R)-(+)-enantiomer of (±)-Bay K 8644

(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Enantiomer showing opposite effects to the racemate (±)-Bay K 8644 (Cat. No. 1544) and (S)-(-)- enantiomer (Cat. No. 1546). Also TMEM176B inhibitor. Induces IL-1β secretion and caspase-1 activation in bone marrow-derived dendritic cells in vitro and increases survival of tumor-bearing mice, both alone and in combination with immune checkpoint blockers.

Racemate and (S)-(-)-Enantiomer also available.

Chemical Identifiers

CAS 98791-67-4
Molecular Formula C16H15F3N2O4

Specifications

Quantity 10 mg
Formula Weight 356.3
Purity >97%
Molecular Weight (g/mol) 356.301
Chemical Name or Material (R)-(+)-Bay K 8644

Safety and Handling

Recommended Storage Store at +4°C
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