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R&D Systems ABT 089 Dihydrochloride, Tocris™

High affinity and selective α4β2 partial agonist

Manufacturer:  R&D Systems 5079/10

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Catalog No. 507910R

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Research Use Only. Not For Human or Veterinary Use



  • Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively
  • Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro
  • Enhances cognitive performance in vivo
  • Orally bioavailable and brain penetrant
Description & Specifications


ABT 089 dihydrochloride
2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Soluble to 100mM in water and to 20mM in DMSO
Bioactive Small Molecules

Safety and Handling

Recommended Storage : Desiccate at room temperature.

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