Tocris Bioscience™ ABT 089 Dihydrochloride
High affinity and selective α4β2 nAChR partial agonist
Supplier: Tocris Bioscience™ 5079/50
DescriptionABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.
|ABT 089 dihydrochloride|
|Soluble to 100mM in water and to 20mM in DMSO|
|Bioactive Small Molecule|
Safety and Handling
Recommended Storage : Desiccate at Room Temperature
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Research Use Only. Not For Human or Veterinary Use