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Tocris Bioscience™ ABT 089 Dihydrochloride

High affinity and selective α4β2 nAChR partial agonist

Manufacturer:  Tocris Bioscience™ 5079/50

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Catalog No. 507950R

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ABT 089 dihydrochloride is a high affinity and selective α4β2 partial agonist (Ki = 16 nM). Exhibits >1000-fold and >10,000-fold selectivity for α4β2 over α1β1γ1 and α7 receptors respectively. Neuroprotective against glutamate-induced toxicity in rat cortical neurons in vitro. Enhances cognitive performance in vivo. Orally bioavailable and brain penetrant.


50 mg
Bioactive Small Molecule
ABT 089 dihydrochloride
2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride
Soluble to 100mM in water and to 20mM in DMSO
Safety and Handling

Safety and Handling

Recommended Storage : Desiccate at Room Temperature

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Research Use Only. Not For Human or Veterinary Use