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Tocris Bioscience™ EPZ 004777

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Quantity:
10 mg
Description
EPZ 004777 is a highly potent DOT1L inhibitor (IC50 = 0.4 nM). Exhibits >1000-fold selectivity for DOT1L over a panel of other methyltransferases. Selectively inhibits proliferation and induces apoptosis of MLL-rearranged cells in vitro. Prolongs survival in a MLL xenograft mouse model. Enhances efficiency of Yamanaka-factor factor reprogramming of fibroblasts by 3-4-fold.
Specifications
Specifications
Chemical Name or Material | EPZ 004777 |
CAS | 1338466-77-5 |
Synonym | 7-[5-Deoxy-5-[[3-[[[[4-(1,1-dimethylethyl)phenyl]amino]carbonyl]amino]propyl](1-methylethyl)amino]-β-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
Quantity | 10 mg |
Solubility | Soluble to 100mM in DMSO and to 100mM in ethanol |
Molecular Formula | C28H41N7O4 |
Formula Weight | 539.67 |
Physical Form | Solid |
Product Type | Bioactive Small Molecule |
Purity | >98% |
Research Use Only. Not For Human or Veterinary Use
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