R&D Systems MK6-83, Tocris™

TRPML channel activator

Manufacturer: R&D Systems 5547/50

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Catalog No. 554750

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Research Use Only. Not For Human or Veterinary Use


    Chemical Name or Material MK6-83
    CAS 1062271-24-2
    Assay Percent Range >98%
    Molecular Formula C16H20N2O2S2
    Formula Weight 336.47
    Synonym 5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
    Recommended Storage Store at +4°C.
    Quantity 50mg
    Solubility Soluble to 100mM in DMSO and to 20mM in ethanol
    Physical Form Solid
    Product Type Bioactive Small Molecules

    • Activates F408 and F465L TRPML mutants (EC50 values are 0.1 and 1.23µM respectively)
    • Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts

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