MilliporeSigma™ Rabbit anti-Aspa/Nur7, Polyclonal,

Rabbit Polyclonal Antibody

Supplier:  MilliporeSigma™ ABN1698

Catalog No. ABN1698MI

Description

Specifically detects Aspa/Nur7 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry, Western Blotting

Aspartoacylase (EC 3.5.1.15; UniProt Q8R3P0; also known as Acy-2, Aminoacylase-2, Nur-7) is encoded by the Aspa (also known as Acy2) gene (Gene ID 11484) in murine species. Aspartoacylase catalyzes the deacetylation of N-acetylaspartate (NAA) to generate free acetate in the central nervous system (CNS). Mutations in the ASPA gene cause the autosomal recessive neurodegenerative Canavan disease (CD) that results in inadequate lipid/myelin synthesis during development. Immunohistochemical staining reveals that aspartoacylase colocalizes with the oligodendrocyte marker CC1 throughout the brain, indicating its role in myelination.

Specifications

• Antigen: Aspa/Nur7
• Classification: Polyclonal
• Gene Accession No.: Q8R3P0
• Host Species: Rabbit
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Form: Purified

• Applications: Immunohistochemistry, Western Blot
• Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
• Gene Symbols: Aspa
• Immunogen: N-terminally his-tagged full-length recombinant mouse Aspa/Nur7.
• Quantity: 100 μg
• Research Discipline: Neuroscience
• Gene ID (Entrez): NP_075602
• Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.

For Research Use Only