BRCA1 (phospho S988), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRCA1.

Supplier:  Abnova Corporation PAB12267

Catalog No. 89-115-682

Description

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq

Sequence: IKSpFV

Specifications

• Antigen: BRCA1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic phosphopeptide of BRCA1.
• Formulation: In PBS (without mg²⁺ and Ca²⁺), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
• Gene Accession No.: P38398
• Gene Symbols: BRCA1
• Immunogen: Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S988 of human BRCA1.
• Regulatory Status: RUO
• Gene ID (Entrez): 672
• Target Species: Human
• Form: Liquid

• Applications: Immunofluorescence
• Conjugate: Unconjugated
• Dilution: Immunofluorescence (1:100-1:200) The optimal working dilution should be determined by the end user.
• Gene: BRCA1
• Gene Alias: BRCAI/BRCC1/IRIS/PSCP/RNF53
• Host Species: Rabbit
• Quantity: 100 μL
• Primary or Secondary: Primary
• Test Specificity: BRCA1 (phospho-Ser988) antibody detects endogenous levels of BRCA1 only when phosphorylated at serine 988.
• Content And Storage: Store at -20°C.
  Aliquot to avoid repeated freezing and thawing.

For Research Use Only