DDR1 Rabbit anti-Human, Monkey, Polyclonal Antibody, Abnova™

Rabbit polyclonal antibody raised against synthetic peptide of DDR1.

Manufacturer:  Abnova Corporation PAB16328

Catalog No. 89-118-200

Description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq

Specifications

• Antigen: DDR1
• Classification: Polyclonal
• Description: Rabbit polyclonal antibody raised against synthetic peptide of DDR1.
• Formulation: In PBS (0.09% sodium azide)
• Gene Accession No.: Q08345
• Gene Symbols: DDR1
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to human DDR1.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Test Specificity: N-terminal region of human.
• Form: Liquid

• Applications: Immunohistochemistry (PFA fixed)
• Conjugate: Unconjugated
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (15-20 ug/mL) The optimal working dilution should be determined by the end user.
• Gene: DDR1
• Gene Alias: CAK/CD167/DDR/EDDR1/MCK10/NEP/NTRK4/PTK3/PTK3A/RTK6/TRKE
• Host Species: Rabbit
• Purification Method: Immunoaffinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 780
• Target Species: Human, Monkey

For Research Use Only