DDR1 Rabbit anti-Human, Monkey, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of DDR1.
Manufacturer: Abnova Corporation PAB16328
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq
|Rabbit polyclonal antibody raised against synthetic peptide of DDR1.|
|In PBS (0.09% sodium azide)|
|A synthetic peptide (conjugated with KLH) corresponding to human DDR1.|
|N-terminal region of human.|
|Immunohistochemistry (PFA fixed)|
|Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (15-20 ug/mL) The optimal working dilution should be determined by the end user.|
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