DDR1 Rabbit anti-Human, Monkey, Polyclonal Antibody, Abnova™

Catalog No.	Quantity
89-118-200	50 μg

Catalog No. 89-118-200 Supplier Abnova Corporation Supplier No. PAB16328

Description

Rabbit polyclonal antibody raised against synthetic peptide of DDR1.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq

Specifications

• Antigen: DDR1
• Applications: Immunohistochemistry (PFA fixed)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Description: Rabbit polyclonal antibody raised against synthetic peptide of DDR1.
• Dilution: Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (15-20 ug/mL) The optimal working dilution should be determined by the end user.
• Formulation: In PBS (0.09% sodium azide)
• Gene: DDR1
• Gene Accession No.: Q08345
• Gene Alias: CAK/CD167/DDR/EDDR1/MCK10/NEP/NTRK4/PTK3/PTK3A/RTK6/TRKE
• Gene Symbols: DDR1
• Host Species: Rabbit
• Immunogen: A synthetic peptide (conjugated with KLH) corresponding to human DDR1.
• Purification Method: Immunoaffinity purification
• Quantity: 50 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 780
• Test Specificity: N-terminal region of human.
• Target Species: Human, Monkey
• Content And Storage: Store at 4°C. For long term storage store at -80°C.
  Aliquot to avoid repeated freezing and thawing.
• Form: Liquid

For Research Use Only