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ERBB2 (phospho Y877), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™

Catalog No. 89126956 Shop All Abnova Corporation Products
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89-126-956 100 μg
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Catalog No. 89-126-956 Supplier Abnova Corporation Supplier No. PAB25294
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERBB2.

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq

Sequence: T-E-Yp-H-A

Specifications

Antigen ERBB2
Applications Immunofluorescence, Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of ERBB2.
Dilution Immunohistochemistry (1:50-1:100) Western Blot (1:500-1:1000) Immunofluorescence (1:100-1:200) The optimal working dilution should be determined by the end user.
Formulation In PBS (without mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene ERBB2
Gene Accession No. P04626
Gene Alias CD340/HER-2/HER-2/neu/HER2/NEU/NGL/TKR1
Gene Symbols ERBB2
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding Y877 of human ERBB2.
Purification Method Affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2064
Target Species Human, Mouse, Rat
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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