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Description
This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq
Specifications
Specifications
| Antigen | GLI3 |
| Applications | ELISA, Immunohistochemistry (PFA fixed), Western Blot |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Description | Rabbit polyclonal antibody raised against synthetic peptide of GLI3. |
| Dilution | ELISA (1:6000-1:30000) Western Blot (1:500-1:2000) Immunohistochemistry (0.5-5 ug/mL) The optimal working dilution should be determined by the end user. |
| Formulation | In 20mM KH2PO4, 150mM NaCl, pH 7.2 (0.01% sodium azide) |
| Gene | GLI3 |
| Gene Accession No. | P10071;NP_000159 |
| Gene Alias | ACLS/GCPS/PAP-A/PAPA/PAPA1/PAPB/PHS/PPDIV |
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