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HTR2C Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89127161 Shop All Abnova Corporation Products
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89-127-161 50 μg
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Catalog No. 89-127-161 Supplier Abnova Corporation Supplier No. PAB25547
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Description

Rabbit polyclonal antibody raised against synthetic peptide of HTR2C.

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq

Specifications

Antigen HTR2C
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of HTR2C.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (3.8 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene HTR2C
Gene Alias 5-HT2C/5-HTR2C/HTR1C
Gene Symbols HTR2C
Host Species Rabbit
Immunogen A synthetic peptide corresponding to 16 amino acids at C-terminus of human HTR2C.
Purification Method Immunoaffinity chromatography
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3358
Test Specificity BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Target Species Human
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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