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MAP3K5 (phospho S83), Rabbit anti-Human, Polyclonal Antibody, Abnova™

Catalog No. 89127020 Shop All Abnova Corporation Products
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89-127-020 100 μg
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Catalog No. 89-127-020 Supplier Abnova Corporation Supplier No. PAB25383
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Description

Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP3K5.

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK. [provided by RefSeq

Sequence: G-S-Sp-V-G

Specifications

Antigen MAP3K5
Applications Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic phosphopeptide of MAP3K5.
Dilution Western Blot (1:500-1:1000) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user.
Formulation In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Gene MAP3K5
Gene Alias ASK1/MAPKKK5/MEKK5
Gene Symbols MAP3K5
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding S83 of human MAP3K5.
Purification Method Affinity purification
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4217
Target Species Human
Content And Storage Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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