MEF2A (phospho S408), Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova
Rabbit polyclonal antibody raised against synthetic phosphopeptide of MEF2A.
Manufacturer: Abnova Corporation PAB25881
The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIMSequence: P-I-Sp-P-P
|Rabbit polyclonal antibody raised against synthetic phosphopeptide of MEF2A.|
|In PBS (without Mg2+ and Ca2+), 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)|
|Synthetic phosphopeptide corresponding to residues surrounding S408 of human MEF2A.|
|Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
|Human, Murine, Rat|
|Immunohistochemistry (PFA fixed)|
|Immunohistochemistry (1:50-1:100) The optimal working dilution should be determined by the end user.|
For Research Use Only