NFKBIB Rabbit anti-Human, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of NFKBIB.
Manufacturer: Abnova Corporation PAB18763
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
|Rabbit polyclonal antibody raised against synthetic peptide of NFKBIB.|
|In buffer containing 0.02% sodium azide|
|ELISA, Western Blot|
|ELISA (1:20000-1:80000) Western Blot (1:200-1:1000) The optimal working dilution should be determined by the end user.|
|A synthetic peptide corresponding to 14 amino acids at C-terminus of human NFKBIB.|
|Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
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