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PYGL Rabbit anti-Dog, Human, Polyclonal Antibody, Abnova™

Catalog No. 89118140 Shop All Abnova Corporation Products
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89-118-140 50 μg
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Catalog No. 89-118-140 Supplier Abnova Corporation Supplier No. PAB16266
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Description

Rabbit polyclonal antibody raised against synthetic peptide of PYGL.

This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, or Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq

Specifications

Antigen PYGL
Applications Immunohistochemistry (PFA fixed)
Classification Polyclonal
Conjugate Unconjugated
Description Rabbit polyclonal antibody raised against synthetic peptide of PYGL.
Dilution Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL) The optimal working dilution should be determined by the end user.
Formulation In PBS (0.09% sodium azide)
Gene PYGL
Gene Alias GSD6
Gene Symbols PYGL
Host Species Rabbit
Immunogen A synthetic peptide (conjugated with KLH) corresponding to human PYGL.
Purification Method Immunoaffinity purification
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5836
Test Specificity Internal domain of human.
Target Species Canine, Human
Content And Storage Store at 4°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.
Form Liquid
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For Research Use Only

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