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MilliporeSigma™ Rabbit anti-Sodium Pump Subunit alpha-2, Polyclonal,

Catalog No. AB9094IMI Shop All MilliporeSigma Products
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Description

Rabbit Polyclonal Antibody

Specifically detects Sodium Pump Subunit alpha-2 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting

Sodium/potassium-transporting ATPase subunit alpha-2 (EC 3.6.3.9; UniProt P06686; also known as Na+/K+ -ATPase alpha 2 subunit, Na+/K+ ATPase alpha(+) subunit, Sodium pump subunit alpha-2) is encoded by the Atp1a2 (also known as RATATPA2) gene (Gene ID 24212) in rat. Mammalian Na+/K+ ATPase is a heteromultimeric complex composed of alpha, beta, and gamma subunits. The alpha subunit catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ across the plasma membrane. The alpha subunit contains ten transmembrane domains with both its N- and C-termini in the cytoplasm. More than 50 mutations have been identified affecting the human ATP1A2 and ATP1A3 genes that are known to cause rapid-onset Dystonia Parkinsonism, familial hemiplegic migraine, alternating hemiplegia of childhood, and variants of familial hemiplegic migraine with neurological complications including seizures and various mood disorders.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Sodium Pump Subunit alpha-2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Formulation Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No. P06686
Gene Symbols Atp1a2
Host Species Rabbit
Immunogen KLH-conjugated linear peptide corresponding to the second cytoplasmic domain of rat Sodium Pump Subunit alpha-2.
Purification Method Affinity Purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Neuroscience
Primary or Secondary Primary
Gene ID (Entrez) NP_036637
Target Species Human, Mouse, Rat
Content And Storage Stable for one year at 2°C to 8°C from date of receipt.
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