RACGAP1 Monoclonal Antibody (OTI4C5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA811640

Catalog No. 50-168-4157

Description

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.

Specifications

• Antigen: RACGAP1
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q9H0H5
• Gene Symbols: RACGAP1
• Immunogen: Human recombit protein fragment corresponding to amino acids 123-238 of human RACGAP1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4C5
• Conjugate: Unconjugated
• Gene: RACGAP1
• Gene Alias: CYK4, HsCYK-4, ID-GAP, MgcRacGAP
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 29127
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid