RAD18 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-2120	150 μL

Catalog No. 50-173-2120 Supplier Proteintech Group Inc Supplier No. 183331AP150UL

Description

Rabbit Polyclonal Antibody

This antibody is specific to RAD18.

Human Rad18 (hRad18) is homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif. It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6. The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.

Specifications

• Antigen: RAD18
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: RAD18
• Gene Accession No.: Q9NS91, Q9QXK2
• Gene Alias: hHR18, hRAD18, RAD18, RAD18 homolog (S. cerevisiae), RING finger protein 73, RNF73
• Gene Symbols: Rad18
• Host Species: Rabbit
• Immunogen: RAD18 Fusion Protein Ag12944
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 362412, 56852, 58186
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG