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Apexbio Technology LLC Ramiprilat 87269-97-4 1mg
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Supplier:  Apexbio Technology LLC C34921

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Ramiprilat (CAS 87269-97-4) is an active metabolite of the ACE inhibitor prodrug ramipril It selectively inhibits angiotensin-converting enzyme (ACE) thereby reducing the formation of angiotensin II a peptide involved in vasoconstriction and aldosterone secretion In human heart ramiprilat demonstrates high binding affinity for ACE (pKi 9 08) In vitro studies indicate that ramiprilat modulates B2 kinin receptor dynamics and decreases [3H]bradykinin binding in endothelial cell membranes In animal models ACE inhibition with ramiprilat ameliorates diabetic renal injury and hypertension Clinically ramiprilat is associated with decreased risk of cardiovascular events supporting its value in cardiovascular and renal research

Catalog No. 50-000-91387


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