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Invitrogen™ RANBP1 Polyclonal Antibody
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Catalog No. PA1080
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100 μg
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PA1080 100 μg
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Catalog No. PA1080 Supplier Invitrogen™ Supplier No. PA1080
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Description

Rabbit Polyclonal Antibody

PA1-080 detects Ran binding protein 1 (RanBP1) from human and mouse cells. PA1-080 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~30 kDa protein representing RanBP1 from HeLa cell extract. The PA1-080 immunogen is a synthetic peptide corresponding to residues M(1) A A A K D T H E D H D T S T E N T(18) C of human RanBP1. The PA1-080 immunizing peptide (Cat. # PEP-128) is available for use in neutralization and control experiments.

Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RANBP1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1mg/mL BSA and 0.05% sodium azide
Gene RANBP1
Gene Accession No. P34022, P43487
Gene Alias HpaII tiny fragments locus 9A; hpaII tiny fragments locus 9a protein; Htf9a; Htf9-a; Htf9-a/RanBP1; RAN binding protein 1; ran-binding protein 1; RANBP1; RANG; Ran-specific GTPase-activating protein; testis secretory sperm-binding protein Li 221n
Gene Symbols RANBP1
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues M(1) A A A K D T H E D H D T S T E N T(18) C of human RanBP1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19385, 5902
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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