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RANBP10 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group Inc 211071AP150UL

Encompass_Preferred

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Catalog No. 50-173-3260


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Description

Description

The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
Specifications

Specifications

RANBP10
Polyclonal
Unconjugated
RANBP10
KIAA1464, RAN binding protein 10, RANBP10
Rabbit
Antigen Affinity Chromatography
RUO
361396, 57610, 74334
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot
0.22 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q6VN19, Q6VN20
Ranbp10
RANBP10 Fusion Protein Ag15387
150 μL
Primary
Human, Mouse, Rat
Antibody
IgG
SDS
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