Invitrogen™ RAP Polyclonal Antibody

Catalog No.	Quantity
PIPA591892	100 μL

Catalog No. PIPA591892 Supplier Invitrogen™ Supplier No. PA591892

Description

Rabbit Polyclonal Antibody

Positive Samples: K-562, THP-1, HepG2; Cellular Location: Cell surface, Cytoplasm, Endoplasmic reticulum Immunogen sequence: GLDEDGEKEA RLIRNLNVIL AKYGLDGKKD ARQVTSNSLS GTQEDGLDDP RLEKLWHKAK TSGKFSGEEL DKLWREFLHH KEKVHEYNVL LETLSRTEEI H.

The term RAP typically refers to receptor-associated protein, encoded by the LRPAP1 gene, which plays a significant role in the trafficking and function of certain receptors within cells. RAP is primarily involved in the regulation of low-density lipoprotein receptor-related proteins (LRPs) by acting as a chaperone during protein transport within the endoplasmic reticulum (ER). It prevents premature ligand binding and assists in the proper folding and assembly of receptor complexes, ensuring efficient receptor function and trafficking to the cell surface. RAP also influences cellular processes related to cholesterol metabolism and cell signaling through its interactions with these receptors. Its function is crucial for transporting and recycling receptors involved in various pathways, including lipid metabolism, endocytosis, and cellular homeostasis. Dysregulation of RAP or related receptor functions can impact metabolic health and are implicated in conditions such as atherosclerosis, neurodegenerative disorders, and cancer.

Specifications

• Antigen: RAP
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.31 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Lrpap1
• Gene Accession No.: P30533, P55302, Q99068
• Gene Alias: 39 kDa receptor-associated protein; A2MRAP; A2RAP; AA617339; AI790446; Alpha-2-macroglobulin receptor-associated protein; Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44); alpha-2-MRAP; AU042172; C77774; gp330-binding 45 kDa protein; HBP44; HBP-44; heparin-binding protein 44; LDL receptor related protein associated protein 1; low density lipoprotein receptor related protein, associated protein 1; low density lipoprotein receptor-related protein associated protein 1; low density lipoprotein receptor-related protein-associated protein 1; low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1); Lrpap1; MRAP; MYP23; RAP
• Gene Symbols: Lrpap1
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human LRPAP1 (P30533).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 116565, 16976, 4043
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov