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Invitrogen™ RAP1GAP Monoclonal Antibody (2G7B6)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA538622
Description
This antibody has been tested in indirect ELISA.
Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
Specifications
RAP1GAP | |
Monoclonal | |
1 mg/mL | |
PBS with 0.05% sodium azide | |
P47736 | |
RAP1GAP | |
Purified recombinant fragment of human RAP1GAP (aa: 412-678) expressed in E. Coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG2b |
ELISA, Flow Cytometry, Western Blot | |
2G7B6 | |
Unconjugated | |
RAP1GAP | |
1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; KIAA0474; RAP1 GTPase activating protein; Rap1 GTPase-activating protein; rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1ga1; Rap1GAP; Rap1GAP1; RAP1GAPII; RAPGAP | |
Mouse | |
Protein G | |
RUO | |
5909 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
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