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RAP1GAP Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS2918R

Catalog No. 50-198-5009


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Description

Description

Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
Specifications

Specifications

RAP1GAP
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
RAP1GAP
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
5909
RAP1GAP
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P47736
1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; Kiaa0474; RAP1 GTPase activating protein; Rap1 GTPase-activating protein; Rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1ga1; RAP1GAP; Rap1GAP1; RAP1GAPII; RAPGAP
KLH conjugated synthetic peptide derived from human RAP1GAP.
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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