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RAP80 Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A300763A

Description
The recommended shelf life for this product is 1 year from date of receipt.
RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.Specifications
RAP80 | |
Polyclonal | |
Unconjugated | |
UIMC1 | |
RAP80, X2HRIP110; BRCA1-A complex subunit RAP80; receptor associated protein 80; receptor-associated protein 80; retinoid X receptor-interacting protein 110; retinoid x receptor interacting protein; ubiquitin interaction motif-containing protein 1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
51720 | |
4° C | |
Liquid |
Immunoprecipitation, Western Blot | |
1 mg/ml | |
phosphate, tris citrate with 0.09% sodium azide; pH 7-8 | |
Q96RL1 | |
UIMC1 | |
Between 600 and 650 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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