RAP80 Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Manufacturer: Bethyl Laboratories, Inc A300763A
The recommended shelf life for this product is 1 year from date of receipt.RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
|Between 600 and 650|
|Antigen affinity chromatography|
|Immunoprecipitation, Western Blot|
|phosphate, tris citrate with 0.09% sodium azide; pH 7-8|
|RAP80, X2HRIP110; BRCA1-A complex subunit RAP80; receptor associated protein 80; receptor-associated protein 80; retinoid X receptor-interacting protein 110; retinoid x receptor interacting protein; ubiquitin interaction motif-containing protein 1|
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